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6,336 results

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Page 1
Dengue virus replication enhances labile zinc pools by modulation of ZIP8.
Panwar A, Wangchuk J, Kar M, Lodha R, Medigeshi GR. Panwar A, et al. Cell Microbiol. 2021 Dec;23(12):e13395. doi: 10.1111/cmi.13395. Epub 2021 Oct 15. Cell Microbiol. 2021. PMID: 34619004 Free PMC article.
Here, we report that the intracellular labile zinc levels were elevated at early stages of dengue virus (DENV) infection in hepatic cells and this increase in free zinc was abolished in cells infected with UV-inactivated virus or with a DENV replicatio …
Here, we report that the intracellular labile zinc levels were elevated at early stages of dengue virus (DENV) infection in he …
Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids.
Casorla-Perez LA, Guennoun R, Cubillas C, Peng B, Kornfeld K, Wang D. Casorla-Perez LA, et al. J Virol. 2022 Nov 23;96(22):e0121122. doi: 10.1128/jvi.01211-22. Epub 2022 Nov 7. J Virol. 2022. PMID: 36342299 Free PMC article.
Mutation of a zinc transporter encoded by sur-7, which suppresses the lipid defect of sbp-1, also rescued Orsay virus infection. ...Interestingly, the human ortholog of sbp-1, srebp-1, has been reported to play a role for virus infection, and zinc has …
Mutation of a zinc transporter encoded by sur-7, which suppresses the lipid defect of sbp-1, also rescued Orsay virus infectio …
Zinc Chelation Specifically Inhibits Early Stages of Dengue Virus Replication by Activation of NF-kappaB and Induction of Antiviral Response in Epithelial Cells.
Kar M, Khan NA, Panwar A, Bais SS, Basak S, Goel R, Sopory S, Medigeshi GR. Kar M, et al. Front Immunol. 2019 Oct 1;10:2347. doi: 10.3389/fimmu.2019.02347. eCollection 2019. Front Immunol. 2019. PMID: 31632411 Free PMC article.
Therefore, depending on the host machinery that the virus employs at different stages of infection, zinc may either facilitate, or inhibit virus infection. ...Time-of-addition experiments suggested that zinc chelation affected both early and late stage …
Therefore, depending on the host machinery that the virus employs at different stages of infection, zinc may either facilitate …
The Role of Micronutrients in Support of the Immune Response against Viral Infections.
Pecora F, Persico F, Argentiero A, Neglia C, Esposito S. Pecora F, et al. Nutrients. 2020 Oct 20;12(10):3198. doi: 10.3390/nu12103198. Nutrients. 2020. PMID: 33092041 Free PMC article. Review.
The main aim of this manuscript is to discuss of the potential role of micronutrients supplementation in supporting immunity, particularly against respiratory virus infections. Literature analysis showed that in vitro and observational studies, and clinical trials, highlig …
The main aim of this manuscript is to discuss of the potential role of micronutrients supplementation in supporting immunity, particularly a …
Hepatitis B Virus X Protein Function Requires Zinc Binding.
Ramakrishnan D, Xing W, Beran RK, Chemuru S, Rohrs H, Niedziela-Majka A, Marchand B, Mehra U, Zábranský A, Doležal M, Hubálek M, Pichová I, Gross ML, Kwon HJ, Fletcher SP. Ramakrishnan D, et al. J Virol. 2019 Jul 30;93(16):e00250-19. doi: 10.1128/JVI.00250-19. Print 2019 Aug 15. J Virol. 2019. PMID: 31167910 Free PMC article.
The host structural maintenance of chromosomes 5/6 complex (Smc5/6) suppresses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing the X protein (HBx), which redirects the cellular DNA damage-binding protein 1 (DDB1)-containing E3 ubiquitin l …
The host structural maintenance of chromosomes 5/6 complex (Smc5/6) suppresses hepatitis B virus (HBV) transcription. HBV counters th …
Zinc-Embedded Polyamide Fabrics Inactivate SARS-CoV-2 and Influenza A Virus.
Gopal V, Nilsson-Payant BE, French H, Siegers JY, Yung WS, Hardwick M, Te Velthuis AJW. Gopal V, et al. ACS Appl Mater Interfaces. 2021 Jul 7;13(26):30317-30325. doi: 10.1021/acsami.1c04412. Epub 2021 Jun 27. ACS Appl Mater Interfaces. 2021. PMID: 34180223 Free PMC article.
Influenza A viruses (IAV) and SARS-CoV-2 can spread via liquid droplets and aerosols. Face masks and other personal protective equipment (PPE) can act as barriers that prevent the spread of these viruses. ...We found that our PA66-based fabric decreased the IAV H1N1 …
Influenza A viruses (IAV) and SARS-CoV-2 can spread via liquid droplets and aerosols. Face masks and other personal protective equipm …
The zinc proteome of SARS-CoV-2.
Andreini C, Arnesano F, Rosato A. Andreini C, et al. Metallomics. 2022 Jul 25;14(7):mfac047. doi: 10.1093/mtomcs/mfac047. Metallomics. 2022. PMID: 35767875 Free PMC article.
Zinc is an essential element for human health. Among its many functions, zinc(II) modulates the immune response to infections and, at high concentrations or in the presence of ionophores, inhibits the replication of various RNA viruses. ...Given the double-ed …
Zinc is an essential element for human health. Among its many functions, zinc(II) modulates the immune response to infections …
Inhibition of hepatitis E virus replication by zinc-finger antiviral Protein synergizes with IFN-beta.
Yu W, Ji H, Long F, Chen S, He Q, Xia Y, Cong C, Yang C, Wei D, Huang F. Yu W, et al. J Viral Hepat. 2021 Aug;28(8):1219-1229. doi: 10.1111/jvh.13522. Epub 2021 May 3. J Viral Hepat. 2021. PMID: 33894039
Hepatitis E virus (HEV) infection is the most common cause of acute viral hepatitis worldwide. However, host-HEV interactions have yet to be fully understood. Zinc-finger antiviral protein (ZAP) is a novel interferon (IFN)-stimulated gene product that inhibits a var …
Hepatitis E virus (HEV) infection is the most common cause of acute viral hepatitis worldwide. However, host-HEV interactions have ye …
Zinc-binding site of human immunodeficiency virus 2 Vpx prevents instability and dysfunction of the protein.
Yamamoto M, Koga R, Fujino H, Shimagaki K, Ciftci HI, Kamo M, Tateishi H, Otsuka M, Fujita M. Yamamoto M, et al. J Gen Virol. 2017 Feb;98(2):275-283. doi: 10.1099/jgv.0.000701. J Gen Virol. 2017. PMID: 28284276
Human immunodeficiency virus 2 Vpx coordinates zinc through residues H39, H82, C87 and C89. We reported previously that H39, H82 and C87 mutants maintain Vpx activity to facilitate the degradation of SAMHD1. Herein, the expression of Vpx mutants in cells was examine …
Human immunodeficiency virus 2 Vpx coordinates zinc through residues H39, H82, C87 and C89. We reported previously that H39, H …
Zinc-binding properties of Junin virus nucleocapsid protein.
Tortorici MA, Ghiringhelli PD, Lozano ME, Albariño CG, Romanowski V. Tortorici MA, et al. J Gen Virol. 2001 Jan;82(Pt 1):121-128. doi: 10.1099/0022-1317-82-1-121. J Gen Virol. 2001. PMID: 11125165
We have expressed the N protein of Junin virus in E. coli and shown that it binds zinc in vitro. This property is in agreement with the presence in the carboxy-terminal region of the N protein of the CX(2)HX(23)CX(4)C sequence, which resembles a classical zinc …
We have expressed the N protein of Junin virus in E. coli and shown that it binds zinc in vitro. This property is in agreement …
6,336 results