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1999 1
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153 results

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Page 1
QT Prolongation, Torsades de Pointes, and Psychotropic Medications: A 5-Year Update.
Beach SR, Celano CM, Sugrue AM, Adams C, Ackerman MJ, Noseworthy PA, Huffman JC. Beach SR, et al. Psychosomatics. 2018 Mar-Apr;59(2):105-122. doi: 10.1016/j.psym.2017.10.009. Epub 2017 Nov 3. Psychosomatics. 2018. PMID: 29275963 Review.
BACKGROUND: Some psychotropic medications have been associated with prolongation of the QT interval and QT prolongation, especially in those with medical illness, and are linked to lethal ventricular arrhythmias, such as Torsades de Pointes (TdP). ...Among at …
BACKGROUND: Some psychotropic medications have been associated with prolongation of the QT interval and QT prolongation, espec …
Antipsychotics and risk of QT prolongation: a pharmacovigilance study.
Bordet C, Garcia P, Salvo F, Touafchia A, Galinier M, Sommet A, Montastruc F. Bordet C, et al. Psychopharmacology (Berl). 2023 Jan;240(1):199-202. doi: 10.1007/s00213-022-06293-4. Epub 2022 Dec 14. Psychopharmacology (Berl). 2023. PMID: 36515735
OBJECTIVES AND METHODS: Using data recorded from 1967 to 2019 in VigiBase , the World Health Organization's Global Individual Case Safety Reports database, we performed disproportionality analysis to investigate the risk of reporting QT prolongation between 20 antipsychoti …
OBJECTIVES AND METHODS: Using data recorded from 1967 to 2019 in VigiBase , the World Health Organization's Global Individual Case Safety Re …
QT interval prolongation in acute antipsychotic poisoning: systematic review and recommendations.
Berling I, Yates C, Hoffman RS, Hatten BW, Roberts DM, Wong A, Hoegberg LCG, Lonati D, Ferrer Dufol AMA, Hayes BD, Isbister GK, Paasma R, Heyerdahl F, Mackenzie CA, Othong R, Stanton M, Smith A, Gosselin S. Berling I, et al. Clin Toxicol (Phila). 2025 Nov;63(11):810-837. doi: 10.1080/15563650.2025.2554950. Epub 2025 Nov 19. Clin Toxicol (Phila). 2025. PMID: 41255343 Free article.
INTRODUCTION: Antipsychotic medications are often associated with QT interval prolongation, which can lead to ventricular dysrhythmias, including torsade de pointes. ...Available data suggest that amisulpride, thioridazine and ziprasidone are associated with …
INTRODUCTION: Antipsychotic medications are often associated with QT interval prolongation, which can lead to ventricular dysrhythmia …
Risk Stratification of QTc Prolongation in Critically Ill Patients Receiving Antipsychotics for the Management of Delirium Symptoms.
Sadlonova M, Beach SR, Funk MC, Rosen JH, Ramirez Gamero AF, Karlson RA, Huffman JC, Celano CM. Sadlonova M, et al. J Intensive Care Med. 2025 Apr;40(4):355-371. doi: 10.1177/08850666231222470. Epub 2023 Dec 21. J Intensive Care Med. 2025. PMID: 38130132 Review.
Among other antipsychotics, those most likely to cause QTc prolongation are iloperidone and ziprasidone, while aripiprazole and lurasidone appear to have minimal risk for QTc prolongation. ...
Among other antipsychotics, those most likely to cause QTc prolongation are iloperidone and ziprasidone, while aripiprazole and luras …
An Updated Safety Review of the Relationship Between Atypical Antipsychotic Drugs, the QTc Interval and Torsades de Pointe As: Implications for Clinical Use.
Melo L, Pillai A, Kompella R, Patail H, Aronow WS. Melo L, et al. Expert Opin Drug Saf. 2024 Sep;23(9):1127-1134. doi: 10.1080/14740338.2024.2392002. Epub 2024 Aug 13. Expert Opin Drug Saf. 2024. PMID: 39126643 Review.
INTRODUCTION: The rising prevalence of psychiatric disorders has resulted in a significant increase in the use of antipsychotic medications. These agents may prolong the corrected QT interval (QTc), running the risk of precipitating ventricular arrhythmias, notably Tors …
INTRODUCTION: The rising prevalence of psychiatric disorders has resulted in a significant increase in the use of antipsychotic medications. …
Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis.
Rogdaki M, McCutcheon RA, D'Ambrosio E, Mancini V, Watson CJ, Fanshawe JB, Carr R, Telesia L, Martini MG, Philip A, Gilbert BJ, Salazar-de-Pablo G, Kyriakopoulos M, Siskind D, Correll CU, Cipriani A, Efthimiou O, Howes OD, Pillinger T. Rogdaki M, et al. Lancet Child Adolesc Health. 2024 Jul;8(7):510-521. doi: 10.1016/S2352-4642(24)00098-1. Lancet Child Adolesc Health. 2024. PMID: 38897716 Free PMC article.
Primary outcomes were mean change from baseline to end of acute treatment in bodyweight, BMI, fasting glucose, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, prolactin, heart rate, systolic blood pressure (SBP), and QT interval corrected for heart rate …
Primary outcomes were mean change from baseline to end of acute treatment in bodyweight, BMI, fasting glucose, total cholesterol, LDL choles …
Agitated Psychiatric Patient.
Pabst BM, Leung C, Frey JA, Yee J. Pabst BM, et al. J Educ Teach Emerg Med. 2020 Oct 15;5(4):S59-S83. doi: 10.21980/J85352. eCollection 2020 Oct. J Educ Teach Emerg Med. 2020. PMID: 37465334 Free PMC article.
Chemical and/or physical restraints are sometimes necessary to ensure patient and staff safety when verbal de-escalation is ineffective, particularly since agitation is the leading cause of hospital staff injuries.2 Chemical restraints have been shown to be less physically trauma …
Chemical and/or physical restraints are sometimes necessary to ensure patient and staff safety when verbal de-escalation is ineffective, par …
Ziprasidone and the corrected QT interval: a comprehensive summary of clinical data.
Camm AJ, Karayal ON, Meltzer H, Kolluri S, O'Gorman C, Miceli J, Tensfeldt T, Kane JM. Camm AJ, et al. CNS Drugs. 2012 Apr 1;26(4):351-65. doi: 10.2165/11599010-000000000-00000. CNS Drugs. 2012. PMID: 22452529
In a comparative study of ziprasidone versus five antipsychotics, the mean QTc increase at steady state maximum concentration (C(max)) for ziprasidone was 15.9 ms. ...METHODS: The following analyses of data were conducted to obtain a comprehensive summary of QTc dat …
In a comparative study of ziprasidone versus five antipsychotics, the mean QTc increase at steady state maximum concentration (C(max) …
Management of psychosis and agitation in medical-surgical patients who have or are at risk for prolonged QT interval.
Ries R, Sayadipour A. Ries R, et al. J Psychiatr Pract. 2014 Sep;20(5):338-44. doi: 10.1097/01.pra.0000454778.29433.7c. J Psychiatr Pract. 2014. PMID: 25226194 Review.
We review the literature on management of psychosis and agitation in medical-surgical patients who have or are at risk for prolonged QT interval, a risk factor for torsade de pointes (TdP), and we describe our protocols for treating these patients. ...Prolonged QTc …
We review the literature on management of psychosis and agitation in medical-surgical patients who have or are at risk for prolonged QT …
Antipsychotic drugs and QT prolongation.
Stöllberger C, Huber JO, Finsterer J. Stöllberger C, et al. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51. doi: 10.1097/01.yic.0000166405.49473.70. Int Clin Psychopharmacol. 2005. PMID: 16096514 Review.
AD may cause serious cardiovascular side-effects, including prolonged QT interval, eventually leading to torsades de pointes (TdP) and sudden death. Epidemiologic data and case-control studies indicate an increased rate of sudden death in psychiatric patients taking …
AD may cause serious cardiovascular side-effects, including prolonged QT interval, eventually leading to torsades de pointes ( …
153 results