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Page 1
An Update on Glutathione's Biosynthesis, Metabolism, Functions, and Medicinal Purposes.
Gasmi A, Nasreen A, Lenchyk L, Lysiuk R, Peana M, Shapovalova N, Piscopo S, Komisarenko M, Shanaida M, Smetanina K, Antonyak H, Fira L, Lykhatskyi P, Fira D, Bjørklund G. Gasmi A, et al. Curr Med Chem. 2024;31(29):4579-4601. doi: 10.2174/0109298673251025230919105818. Curr Med Chem. 2024. PMID: 37921175 Review.
Glutathione (GSH) has been the focus of increased scientific interest in the last decades. ...
Glutathione (GSH) has been the focus of increased scientific interest in the last decades. ...
Peroxidase-catalyzed-3-(glutathion-S-yl)-p,p'-biphenol formation.
McGirr LG, Subrahmanyam VV, Moore GA, O'Brien PJ. McGirr LG, et al. Chem Biol Interact. 1986 Oct 15;60(1):85-99. doi: 10.1016/0009-2797(86)90019-0. Chem Biol Interact. 1986. PMID: 3779886
The major glutathione conjugate was identified as 3-(glutathion-S-yl)-p,p'-biphenol by high field nuclear magnetic resonance and fast atom bombardment mass spectrometry. The same conjugate was formed in the bone marrow homogenate-hydrogen peroxide system. p,p'-Biphe …
The major glutathione conjugate was identified as 3-(glutathion-S-yl)-p,p'-biphenol by high field nuclear magnetic resonance a …
Intravenous Glutathione and Vitamin Supplementation Causing Stevens-Johnson Syndrome: A Case Report.
Johnson JS, Jarvis NR, Martinez AM, Dvorak JE. Johnson JS, et al. J Burn Care Res. 2025 Aug 12;46(3):652-655. doi: 10.1093/jbcr/iraf027. J Burn Care Res. 2025. PMID: 40057759
Here we report a case of a 33-year-old female who developed Stevens-Johnson/toxic epidermal necrolysis after receiving an IV vitamin infusion containing glutathione, vitamin C, and vitamin D. While not commonly associated with the development of Stevens-Johnson syndrome, …
Here we report a case of a 33-year-old female who developed Stevens-Johnson/toxic epidermal necrolysis after receiving an IV vitamin infusio …
Mechanism of 3-(glutathion-S-yl)-benzidine formation.
Lakshmi VM, Zenser TV, Davis BB. Lakshmi VM, et al. Toxicol Appl Pharmacol. 1994 Apr;125(2):256-63. doi: 10.1006/taap.1994.1071. Toxicol Appl Pharmacol. 1994. PMID: 8171433
Experiments with [3H]glutathione indicated that conjugate formation was dependent upon diimine, and not benzidine. ...The results are consistent with the existence of the charge-transfer complex and with benzidinediimine reacting with glutathione to form BZ-SG....
Experiments with [3H]glutathione indicated that conjugate formation was dependent upon diimine, and not benzidine. ...The results are …
Cell-specific regulation of Nrf2 during ROS-Dependent cell death caused by 2,3,5-tris(glutathion-S-yl)hydroquinone (TGHQ).
Zhang F, Munoz FM, Sun L, Zhang S, Lau SS, Monks TJ. Zhang F, et al. Chem Biol Interact. 2019 Apr 1;302:1-10. doi: 10.1016/j.cbi.2019.01.027. Epub 2019 Jan 28. Chem Biol Interact. 2019. PMID: 30703377
2,3,5-tris(Glutathion-S-yl)hydroquinone (TGHQ), a potent nephrotoxic and nephroncarcinogenic metabolite of benzene and hydroquinone, retains the ability to redox cycle and create oxidative stress. ...
2,3,5-tris(Glutathion-S-yl)hydroquinone (TGHQ), a potent nephrotoxic and nephroncarcinogenic metabolite of benzene and hydroquinone, …
Glutathione in Brain Disorders and Aging.
Iskusnykh IY, Zakharova AA, Pathak D. Iskusnykh IY, et al. Molecules. 2022 Jan 5;27(1):324. doi: 10.3390/molecules27010324. Molecules. 2022. PMID: 35011559 Free PMC article. Review.
Glutathione exists in two states-oxidized and reduced. Under normal physiological conditions of cellular homeostasis, glutathione remains primarily in its reduced form. ...The exact mechanisms through which glutathione regulates brain metabolism are not well …
Glutathione exists in two states-oxidized and reduced. Under normal physiological conditions of cellular homeostasis, glutathione …
Preservation solutions for transplantation.
Mühlbacher F, Langer F, Mittermayer C. Mühlbacher F, et al. Transplant Proc. 1999 Aug;31(5):2069-70. doi: 10.1016/s0041-1345(99)00265-1. Transplant Proc. 1999. PMID: 10455972 Review.
However, the disadvantage of high viscosity, high price, uneasy handling of many 1-L bags, and the fact that the radical scavenger glutathion cannot be detected in the bags by chemical analysis (presumably due to diffusion) encourage competitors to produce new compounds wi …
However, the disadvantage of high viscosity, high price, uneasy handling of many 1-L bags, and the fact that the radical scavenger glutat …
Glutathione: subcellular distribution and membrane transport (1).
Oestreicher J, Morgan B. Oestreicher J, et al. Biochem Cell Biol. 2019 Jun;97(3):270-289. doi: 10.1139/bcb-2018-0189. Epub 2018 Nov 14. Biochem Cell Biol. 2019. PMID: 30427707 Review.
Whilst glutathione transport is essential for the supply and replenishment of subcellular glutathione pools, recent evidence supports a more active role for glutathione transport in the regulation of subcellular glutathione redox homeostasis. ...In thi …
Whilst glutathione transport is essential for the supply and replenishment of subcellular glutathione pools, recent evidence s …
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