Which topical microbicides for blocking HIV-1 transmission will work in the real world?

PLoS Med. 2006 Sep;3(9):e351. doi: 10.1371/journal.pmed.0030351.

Abstract

Klasse and colleagues discuss key research on the four crucial issues in developing a microbicide: safety, acceptability, efficacy, and affordability.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents, Local / administration & dosage
  • Anti-Infective Agents, Local / therapeutic use*
  • Clinical Trials as Topic
  • Drug Evaluation, Preclinical
  • HIV Infections / prevention & control*
  • HIV Infections / transmission
  • HIV-1 / drug effects*
  • Humans
  • Macaca
  • Models, Theoretical
  • Treatment Outcome

Substances

  • Anti-Infective Agents, Local