Abstract
The effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on herpes simplex virus type 1 DNA and protein synthesis was studied. Ganciclovir markedly inhibited the synthesis of viral DNA and gamma proteins in a dose-dependent manner. However, the synthesis of viral beta proteins was significantly increased by ganciclovir in the later stage of infection.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acyclovir / analogs & derivatives*
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Acyclovir / pharmacology
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Animals
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Antiviral Agents / pharmacology*
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Autoradiography
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DNA, Viral / biosynthesis*
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Electrophoresis, Polyacrylamide Gel
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Ganciclovir
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Simplexvirus / drug effects*
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Simplexvirus / genetics
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Simplexvirus / metabolism
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Vero Cells
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Viral Proteins / biosynthesis*
Substances
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Antiviral Agents
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DNA, Viral
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Viral Proteins
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Ganciclovir
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Acyclovir