Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma

B A C van Dijk; L J Schouten; E Oosterwijk; C A Hulsbergen-van de Kaa; L A L M Kiemeney; R A Goldbohm; J A Schalken; P A van den Brandt

doi:10.1038/sj.bjc.6603281

Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma

Br J Cancer. 2006 Aug 7;95(3):374-7. doi: 10.1038/sj.bjc.6603281.

Authors

B A C van Dijk¹, L J Schouten, E Oosterwijk, C A Hulsbergen-van de Kaa, L A L M Kiemeney, R A Goldbohm, J A Schalken, P A van den Brandt

Affiliation

¹ Department of Epidemiology, NUTRIM, Maastricht University, PO Box 616, Maastricht 6200 MD, The Netherlands.

Abstract

We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Carcinoma, Renal Cell / epidemiology
Carcinoma, Renal Cell / genetics*
Cohort Studies
Female
Humans
Japan / epidemiology
Kidney Neoplasms / epidemiology
Kidney Neoplasms / genetics*
Male
Middle Aged
Multivariate Analysis
Mutation
Risk Factors
Smoking / adverse effects*
Smoking / epidemiology
Von Hippel-Lindau Tumor Suppressor Protein / genetics*

Substances

Von Hippel-Lindau Tumor Suppressor Protein