Abstract
Eighteen carbapenem-resistant, OXA-48-positive enterobacterial isolates recovered from Turkey, Lebanon, Egypt, France, and Belgium were analyzed. In most isolates, similar 70-kb plasmids carrying the carbapenemase gene bla(OXA-48) were identified. That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Belgium / epidemiology
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Carbapenems / pharmacology*
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DNA Transposable Elements / genetics
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Egypt / epidemiology
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Enterobacteriaceae / drug effects*
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / genetics
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Enterobacteriaceae / isolation & purification
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Enterobacteriaceae Infections / epidemiology*
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Enterobacteriaceae Infections / microbiology
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Enterobacteriaceae Infections / transmission
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France / epidemiology
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Humans
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Lebanon / epidemiology
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Microbial Sensitivity Tests / methods
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Plasmids / genetics*
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Turkey / epidemiology
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beta-Lactam Resistance / genetics*
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Carbapenems
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DNA Transposable Elements
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beta-Lactamases
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oxacillinase