In the title compound, C(18)H(22)N(4)O(2), the piperizine ring adopts a chair conformation and the dihedral angle between the pyridine and benzene rings is 67.6 (9)°. The conformations of the attachment of the anisole and N-ethyl-pyridin-2-amine groups to the piperazine ring are (+)anti-periplanar. Intra-molecular C-H⋯O and N-H⋯N inter-actions occur. In the crystal, inter-molecular C-H⋯N hydrogen bonds are present. There are two crystallographically independent but identical mol-ecules per asymmetric unit.