Abstract
Mycobacterium tuberculosis isolates cultured from 6 patients associated with an isoniazid-resistant M. tuberculosis outbreak acquired rifampicin resistance. The rpoB gene sequence showed that resistance was associated with rare mutations in each isolate. Three isolates had a mutation outside the rifampicin resistance-determining region.
MeSH terms
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Antitubercular Agents / pharmacology*
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Base Sequence
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DNA-Directed RNA Polymerases / genetics
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Disease Outbreaks*
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Drug Resistance, Bacterial*
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Humans
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Isoniazid / pharmacology
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London / epidemiology
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Molecular Sequence Data
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Mutation
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / isolation & purification
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Rifampin / pharmacology*
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Tuberculosis, Multidrug-Resistant / epidemiology*
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Tuberculosis, Multidrug-Resistant / microbiology
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Tuberculosis, Pulmonary / epidemiology*
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Tuberculosis, Pulmonary / microbiology
Substances
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Antitubercular Agents
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DNA-Directed RNA Polymerases
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RNA polymerase beta subunit
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Isoniazid
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Rifampin