Age, plasticity, and homeostasis in childhood brain disorders

Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2760-73. doi: 10.1016/j.neubiorev.2013.09.010. Epub 2013 Oct 3.

Abstract

It has been widely accepted that the younger the age and/or immaturity of the organism, the greater the brain plasticity, the young age plasticity privilege. This paper examines the relation of a young age to plasticity, reviewing human pediatric brain disorders, as well as selected animal models, human developmental and adult brain disorder studies. As well, we review developmental and childhood acquired disorders that involve a failure of regulatory homeostasis. Our core arguments are as follows:

Keywords: Age at brain injury; Childhood-acquired brain damage; Homeostasis; Neurodevelopmental disorders; Plasticity; Time since brain injury.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aging*
  • Brain Diseases / physiopathology*
  • Child
  • Homeostasis / physiology*
  • Humans
  • Neuronal Plasticity / physiology*