Integrating host gene expression and the microbiome to explore disease pathogenesis

Allyson L Byrd; Julia A Segre

doi:10.1186/s13059-015-0625-1

Integrating host gene expression and the microbiome to explore disease pathogenesis

Genome Biol. 2015 Apr 8;16(1):70. doi: 10.1186/s13059-015-0625-1.

Authors

Allyson L Byrd¹, Julia A Segre²

Affiliations

¹ Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, Bethesda, MD, 20892, USA. allyson.byrd@nih.gov.
² Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, Bethesda, MD, 20892, USA. jsegre@nhgri.nih.gov.

Abstract

In a recent study, rich clinical assessment and longitudinal study design are combined with host gene expression and microbial sequencing analyses to develop a framework for exploring disease etiology and outcomes in the context of human inflammatory disease.See related article: http://dx.doi.org/10.1186/s13059-015-0637-x.

MeSH terms

Gene Expression Regulation, Bacterial
Host-Parasite Interactions / genetics*
Humans
Inflammation / genetics*
Inflammation / microbiology
Inflammation / pathology
Microbiota / genetics*