SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

Qilin Ao; Wenjing Su; Shuang Guo; Lei Cai; Lei Huang

doi:10.1038/srep16396

SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

Sci Rep. 2015 Nov 9:5:16396. doi: 10.1038/srep16396.

Authors

Qilin Ao¹, Wenjing Su², Shuang Guo³, Lei Cai¹, Lei Huang⁴

Affiliations

¹ Institute of Pathology of Tongji Hospital and Department of Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
² Department of Pathology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
³ Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
⁴ Department of Obstetrics &Gynecology, Central Hospital of Wuhan, Wuhan 430014, China.

Abstract

Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1α by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1α and plays a negative role in ovarian cancer chemotherapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / pharmacology*
Cell Hypoxia
Cell Line, Tumor
Cisplatin / pharmacology*
Cysteine Endopeptidases
Drug Resistance, Neoplasm* / genetics
Endopeptidases / genetics*
Endopeptidases / metabolism
Female
Gene Expression Regulation, Neoplastic / drug effects*
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Ovarian Neoplasms / genetics*
Ovarian Neoplasms / metabolism
Sumoylation

Substances

Antineoplastic Agents
Hypoxia-Inducible Factor 1, alpha Subunit
Endopeptidases
SENP1 protein, human
Cysteine Endopeptidases
Cisplatin