Hybrid Intercalated Duct Lesion of the Parotid: Diagnostic Challenges of a Recently Described Entity with Fine Needle Aspiration Findings

Head Neck Pathol. 2016 Jun;10(2):269-74. doi: 10.1007/s12105-015-0663-8. Epub 2015 Oct 17.

Abstract

Intercalated duct lesions (IDL) of the salivary glands are recently described, and encompass both hyperplasia and benign neoplasms that remain incompletely understood. IDLs have been linked to various benign and low-grade malignant salivary gland neoplasms. We herein present a case of a 77 year old woman with an IDL of the parotid composed of both a hyperplastic and an adenomatous component and report, for the first time, the fine needle aspiration findings of such a lesion. This case illustrates the morphologic spectrum of an IDL, as well as challenges in rendering an accurate cytological and histologic diagnosis. The potential diagnostic pitfalls presented by the hybrid pattern of this lesion are also discussed.

Keywords: Fine needle aspiration cytology; Intercalated duct adenoma; Intercalated duct hyperplasia; Intercalated duct lesion; Parotid; Salivary gland.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / pathology*
  • Aged
  • Biomarkers, Tumor / analysis
  • Biopsy, Fine-Needle
  • Carcinoma / pathology
  • Carcinoma / therapy
  • Carcinoma, Papillary
  • Female
  • Humans
  • Hyperplasia / pathology*
  • Immunohistochemistry
  • Iodine Radioisotopes / therapeutic use
  • Neoplasms, Second Primary / pathology*
  • Parotid Neoplasms / pathology*
  • Thyroid Cancer, Papillary
  • Thyroid Neoplasms / pathology
  • Thyroid Neoplasms / therapy

Substances

  • Biomarkers, Tumor
  • Iodine Radioisotopes