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Enhanced induction of telomerase-specific CD4(+) T cells using dendritic cells transfected with RNA encoding a chimeric gene product.
Su Z, Vieweg J, Weizer AZ, Dahm P, Yancey D, Turaga V, Higgins J, Boczkowski D, Gilboa E, Dannull J. Su Z, et al. Cancer Res. 2002 Sep 1;62(17):5041-8. Cancer Res. 2002. PMID: 12208759
In this study, we sought to determine whether human DCs transfected with mRNA encoding a chimeric hTERT/lysosome-associated membrane protein (LAMP-1) protein, carrying the endosomal/lysosomal sorting signal of the LAMP-1, are capable of stimulating concomitan …
In this study, we sought to determine whether human DCs transfected with mRNA encoding a chimeric hTERT/lysosome-associated me …
Langerhans-type and monocyte-derived human dendritic cells have different susceptibilities to mRNA electroporation with distinct effects on maturation and activation: implications for immunogenicity in dendritic cell-based immunotherapy.
Chung DJ, Romano E, Pronschinske KB, Shyer JA, Mennecozzi M, St Angelo ET, Young JW. Chung DJ, et al. J Transl Med. 2013 Jul 9;11:166. doi: 10.1186/1479-5876-11-166. J Transl Med. 2013. PMID: 23837662 Free PMC article.
Clinical responses to electroporated moDC vaccines, however, have been suboptimal. Human Langerhans-type DCs (LCs) are the most potent conventional DC subtype for inducing CD8+ cytotoxic T lymphocytes (CTLs) in vitro. We recently demonstr …
Clinical responses to electroporated moDC vaccines, however, have been suboptimal. Human Langerhans-type DCs (LCs) are the most poten …
Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand.
Dannull J, Nair S, Su Z, Boczkowski D, DeBeck C, Yang B, Gilboa E, Vieweg J. Dannull J, et al. Blood. 2005 Apr 15;105(8):3206-13. doi: 10.1182/blood-2004-10-3944. Epub 2004 Dec 23. Blood. 2005. PMID: 15618466 Free article.
The objective of this study was to investigate whether the immunostimulatory properties of human monocyte-derived dendritic cells (DCs) could be enhanced by triggering OX40/OX40L signaling. Since monocyte-derived DCs possess only low-cell surface levels of OX40L in …
The objective of this study was to investigate whether the immunostimulatory properties of human monocyte-derived dendritic cells …