Composition of the fat-free mass in obese and nonobese children: matched case-control analyses

Int J Obes (Lond). 2005 Jan;29(1):29-36. doi: 10.1038/sj.ijo.0802834.

Abstract

Objective: Most body composition techniques assume constant properties of the fat-free mass (FFM), such as hydration, density and mineralisation. Previous studies suggested that FFM composition may change in childhood obesity; however, this issue has not been investigated in detail.

Aim: To compare FFM composition in obese and nonobese children.

Design: Observational matched case-control analyses.

Subjects: A total of 28 obese children (13 boys, 15 girls) and 22 nonobese children (10 boys, 12 girls) aged 7-14 y. Obesity was defined as body mass index centile >95.

Methods: Measurements were made of weight, height, total body water, and body volume. Bone mineral content was estimated in a subsample. Body composition was calculated using three- and four-component models.

Results: According to the three-component model (n=22 matched pairs), obese children had greater hydration (P<0.05), and reduced density (P=0.057) of FFM. According to the four component model (n=11 pairs), obese children had greater hydration (P<0.01) and reduced density (P<0.002) of FFM. The mineralisation of FFM was increased, but not significantly so.

Conclusion: The greater hydration and reduced density of FFM of obese children should be taken into account if body composition is to be measured with optimum accuracy during treatment programmes. These differences may be addressed by using multicomponent rather than two-component models of body composition. Although the greater mineralisation of FFM in obese children was not significant in the present study, the four-component model is best able to address the combined differences in hydration and mineralisation that occur in childhood obesity.

MeSH terms

  • Absorptiometry, Photon
  • Adolescent
  • Body Composition*
  • Body Water
  • Case-Control Studies
  • Child
  • Female
  • Humans
  • Male
  • Models, Biological
  • Obesity / physiopathology*
  • Plethysmography
  • Reference Values