Fever: links with an ancient receptor

Curr Biol. 1999 Feb 25;9(4):R147-50. doi: 10.1016/s0960-9822(99)80085-2.

Abstract

Recent advances have provided evidence that prostaglandin E2 mediates the generation of fever in response to interleukin-1 or lipopolysaccharide and have reinforced the similarities of signaling downstream of these two pyrogens.

Publication types

  • Review

MeSH terms

  • Animals
  • Body Temperature Regulation
  • Cytokines / physiology
  • Dinoprostone / physiology*
  • Fever / physiopathology*
  • Humans
  • Interleukin-1
  • Lipopolysaccharides
  • Models, Biological
  • Pyrogens
  • Receptors, Prostaglandin E / physiology*
  • Signal Transduction / physiology*

Substances

  • Cytokines
  • Interleukin-1
  • Lipopolysaccharides
  • Pyrogens
  • Receptors, Prostaglandin E
  • Dinoprostone