Immune signalling: SHP-2 docks at multiple ports

G Huyer; D R Alexander

doi:10.1016/s0960-9822(99)80080-3

Immune signalling: SHP-2 docks at multiple ports

Curr Biol. 1999 Feb 25;9(4):R129-32. doi: 10.1016/s0960-9822(99)80080-3.

Authors

G Huyer¹, D R Alexander

Affiliation

¹ Laboratory of Lymphocyte Signalling and Development Molecular Immunology Programme The Babraham Institute Babraham Cambridge CB2 4AT UK.

PMID: 10074424
DOI: 10.1016/s0960-9822(99)80080-3

Abstract

The protein tyrosine phosphatase SHP-2 functions in many diverse signalling pathways. The recent identification of a SHP-2-binding protein as a homologue of the Grb2-associated adaptor protein Gab1 sheds light on the role of SHP-2 in immune signalling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Calcium-Calmodulin-Dependent Protein Kinases / metabolism
Humans
Intracellular Signaling Peptides and Proteins
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases / physiology*
SH2 Domain-Containing Protein Tyrosine Phosphatases
Signal Transduction / immunology*
src Homology Domains

Substances

Intracellular Signaling Peptides and Proteins
Calcium-Calmodulin-Dependent Protein Kinases
PTPN11 protein, human
PTPN6 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases
SH2 Domain-Containing Protein Tyrosine Phosphatases