Soft tissue sarcomas are uncommon malignancies found in 2/100,000 Americans. The accurate early diagnosis, adequate surgical resection and radiation treatment is associated with a good prognosis in low-grade sarcomas and a fair prognosis in high-grade sarcomas. This monograph will discuss the principles of diagnosis, clinical presentation, adequate surgical management, radiation therapy principles and role of chemotherapy in adult patients with soft tissue sarcomas of the superficial trunk and extremities. Management of metastatic disease will also be discussed.