Antitumor agents 187: synthesis and cytotoxicity of substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds

Bioorg Med Chem Lett. 1999 Mar 8;9(5):713-6. doi: 10.1016/s0960-894x(99)00065-7.

Abstract

Several substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-ones and related compounds were synthesized and evaluated for their in vitro cytotoxicity against a panel of human tumor cell lines. The most active compound (3) showed significant cytotoxic activity with GI50 values in the micromolar range.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Cell Division / drug effects
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Inhibitory Concentration 50
  • KB Cells
  • Pyrans / chemical synthesis*
  • Pyrans / pharmacology
  • Quinolines / chemical synthesis*
  • Quinolines / pharmacology
  • Tumor Cells, Cultured

Substances

  • 8,8-dimethyl-2H,8H-pyrano(6,5-h)quinoline-2-one
  • Antineoplastic Agents
  • Pyrans
  • Quinolines