Neuropeptide Y inhibits glutamate release and long-term potentiation in rat dentate gyrus

Brain Res. 1999 May 8;827(1-2):229-33. doi: 10.1016/s0006-8993(99)01302-5.

Abstract

The effect of intracerebroventricular injection of neuropeptide Y (NPY) was assessed on LTP in dentate gyrus. We report that NPY attenuated LTP and inhibited KCl-induced glutamate release in synaptosomes prepared from dentate gyrus. Activity of the stress-activated kinase, c-Jun NH2-terminal kinase (JNK) in synaptosomes was increased by incubation with NPY or following intracerebroventricular injection. Activation of JNK might underlie the inhibitory effect of NPY on LTP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Appetite Stimulants / pharmacology*
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Dentate Gyrus / chemistry
  • Dentate Gyrus / physiology*
  • Enzyme Activation / drug effects
  • Glutamic Acid / metabolism*
  • JNK Mitogen-Activated Protein Kinases*
  • Long-Term Potentiation / drug effects*
  • MAP Kinase Kinase 4
  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinase Kinases*
  • Mitogen-Activated Protein Kinases*
  • Neuropeptide Y / pharmacology*
  • Potassium Chloride / pharmacology
  • Protein Kinases / metabolism
  • Rats
  • Rats, Wistar
  • Synapses / chemistry
  • Synapses / enzymology
  • Synaptosomes / chemistry
  • Synaptosomes / enzymology

Substances

  • Appetite Stimulants
  • Neuropeptide Y
  • Glutamic Acid
  • Potassium Chloride
  • Protein Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase 4
  • Mitogen-Activated Protein Kinase Kinases