Abstract
Constitutive signal transduction by B cell antigen-receptors and/or their surrogates appears to be critical for progression through multiple developmental checkpoints and for survival of mature B cells in the periphery. Antigen-induced signaling via the B cell receptor can compensate for defects in constitutive signaling and initiates receptor editing, apoptosis and anergy in normal mice - purging the repertoire of autoreactive cells. Thus development and survival of mature B cells seem to require continuous receptor signaling of a defined amplitude.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, CD / physiology
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B-Lymphocytes / physiology*
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CD79 Antigens
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Enzyme Precursors / physiology
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Humans
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Intracellular Signaling Peptides and Proteins
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Mice
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Protein-Tyrosine Kinases / physiology
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Receptors, Antigen, B-Cell / physiology*
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Signal Transduction*
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Syk Kinase
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src-Family Kinases / physiology
Substances
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Antigens, CD
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CD79 Antigens
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CD79A protein, human
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Cd79a protein, mouse
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Enzyme Precursors
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Intracellular Signaling Peptides and Proteins
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Receptors, Antigen, B-Cell
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Protein-Tyrosine Kinases
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SYK protein, human
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Syk Kinase
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Syk protein, mouse
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src-Family Kinases