Abstract
Bone morphogenetic proteins (BMPs) comprise a rapidly expanding subclass of the transforming growth factor-beta superfamily. They are known to regulate a diverse range of developmental phenomena including cell differentiation, morphogenesis and apoptosis. In this study, we have isolated a zebrafish homolog of BMP type IB receptor (BMPR-IB) and examined the localization of the transcripts during embryogenesis. Whole-mount in situ hybridization analysis revealed that unlike other type I and type II receptors that mediate BMP signal, it is expressed in developing somite and in mid-hind brain region in a restricted manner.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Bone Morphogenetic Protein Receptors, Type I
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Cloning, Molecular
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Gene Expression Regulation, Developmental
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Gene Expression Regulation, Enzymologic
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Humans
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In Situ Hybridization
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Mesencephalon / embryology
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Mesencephalon / enzymology
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Molecular Sequence Data
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Phylogeny
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Protein Serine-Threonine Kinases / genetics*
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Receptors, Growth Factor / genetics*
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Somites / enzymology
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Zebrafish / embryology*
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Zebrafish / genetics*
Substances
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Receptors, Growth Factor
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Protein Serine-Threonine Kinases
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BMPR1B protein, human
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Bone Morphogenetic Protein Receptors, Type I