Abstract
The effect of suplatast tosilate (IPD-1151T), which is known to suppress interleukin (IL)-4 release from T cells, on the release of IL-4 and IL-13 from human peripheral basophils was investigated. Basophils were obtained from 16 mite-sensitive atopic asthmatic patients. IPD-1151T clearly inhibited the antigen-induced release of IL-13 but not IL-4. These results suggest that IPD-1151T possesses different activity for the regulation of cytokine release in basophils and T cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Animals
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Anti-Allergic Agents / pharmacology*
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Arylsulfonates / pharmacology*
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Asthma / blood
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Asthma / immunology
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Basophils / cytology
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Basophils / drug effects*
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Basophils / metabolism
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Female
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Histamine Release / drug effects
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Humans
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Interleukin-13 / metabolism*
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Interleukin-4 / metabolism*
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Male
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Middle Aged
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Mites / immunology
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Sulfonium Compounds / pharmacology*
Substances
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Anti-Allergic Agents
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Arylsulfonates
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Interleukin-13
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Sulfonium Compounds
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Interleukin-4
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suplatast tosilate