IPD-1151T (suplatast tosilate) inhibits interleukin (IL)-13 release but not IL-4 release from basophils

Jpn J Pharmacol. 1999 Apr;79(4):501-4. doi: 10.1254/jjp.79.501.

Abstract

The effect of suplatast tosilate (IPD-1151T), which is known to suppress interleukin (IL)-4 release from T cells, on the release of IL-4 and IL-13 from human peripheral basophils was investigated. Basophils were obtained from 16 mite-sensitive atopic asthmatic patients. IPD-1151T clearly inhibited the antigen-induced release of IL-13 but not IL-4. These results suggest that IPD-1151T possesses different activity for the regulation of cytokine release in basophils and T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Anti-Allergic Agents / pharmacology*
  • Arylsulfonates / pharmacology*
  • Asthma / blood
  • Asthma / immunology
  • Basophils / cytology
  • Basophils / drug effects*
  • Basophils / metabolism
  • Female
  • Histamine Release / drug effects
  • Humans
  • Interleukin-13 / metabolism*
  • Interleukin-4 / metabolism*
  • Male
  • Middle Aged
  • Mites / immunology
  • Sulfonium Compounds / pharmacology*

Substances

  • Anti-Allergic Agents
  • Arylsulfonates
  • Interleukin-13
  • Sulfonium Compounds
  • Interleukin-4
  • suplatast tosilate