Abstract
Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apolipoproteins / metabolism
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Arteriosclerosis / etiology
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CD36 Antigens
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Cholesterol / metabolism*
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Cholesterol Esters / metabolism
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Humans
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Lipoproteins, HDL / metabolism
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Membrane Proteins*
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Receptors, Immunologic / metabolism*
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Receptors, Immunologic / physiology
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Receptors, Lipoprotein*
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Receptors, Scavenger
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Scavenger Receptors, Class B
Substances
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Apolipoproteins
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CD36 Antigens
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Cholesterol Esters
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HDL cholesteryl ester
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Lipoproteins, HDL
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Membrane Proteins
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Receptors, Immunologic
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Receptors, Lipoprotein
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Receptors, Scavenger
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Scarb1 protein, mouse
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Scavenger Receptors, Class B
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Cholesterol