Scavenger receptor BI and cholesterol trafficking

Curr Opin Lipidol. 1999 Aug;10(4):329-39. doi: 10.1097/00041433-199908000-00007.

Abstract

Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apolipoproteins / metabolism
  • Arteriosclerosis / etiology
  • CD36 Antigens
  • Cholesterol / metabolism*
  • Cholesterol Esters / metabolism
  • Humans
  • Lipoproteins, HDL / metabolism
  • Membrane Proteins*
  • Receptors, Immunologic / metabolism*
  • Receptors, Immunologic / physiology
  • Receptors, Lipoprotein*
  • Receptors, Scavenger
  • Scavenger Receptors, Class B

Substances

  • Apolipoproteins
  • CD36 Antigens
  • Cholesterol Esters
  • HDL cholesteryl ester
  • Lipoproteins, HDL
  • Membrane Proteins
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Scavenger
  • Scarb1 protein, mouse
  • Scavenger Receptors, Class B
  • Cholesterol