Simultaneous indocyanine green and fluorescein angiography in retinal pigment epithelium tear using the confocal scanning laser ophthalmoscope

Am J Ophthalmol. 1999 Sep;128(3):331-9. doi: 10.1016/s0002-9394(99)00176-2.

Abstract

Purpose: To describe the indocyanine green angiographic pattern of retinal pigment epithelium tears in the setting of age-related macular degeneration compared with the fluorescein angiographic features.

Methods: Twelve consecutive patients (12 eyes) with a retinal pigment epithelium tear underwent simultaneous indocyanine green angiography and fluorescein angiography with the confocal scanning laser ophthalmoscope. The findings for the two modes were compared.

Results: Choroidal neovascular membrane was evident beneath the rolled retinal pigment epithelium on indocyanine green angiograms in 11(92%) of 12 eyes: a focal neovascular membrane was apparent in five (42%) of 12 eyes, whereas a plaque neovascular membrane was seen in six (50%) of 12 eyes. In comparison, fluorescein angiography demonstrated late leakage as a result of occult choroidal neovascular membrane in nine (82%) of 11 eyes but no well-defined choroidal neovascular membrane.

Conclusions: Indocyanine green angiography is superior to fluorescein angiography for imaging choroidal neovascularization in cases of retinal pigment epithelium tear and may serve as an important adjunct to indocyanine green-guided laser treatment in selected cases.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Capillary Permeability
  • Choroidal Neovascularization / diagnosis
  • Choroidal Neovascularization / etiology
  • Cohort Studies
  • Female
  • Fluorescein Angiography*
  • Humans
  • Indocyanine Green*
  • Lasers
  • Macular Degeneration / complications
  • Male
  • Middle Aged
  • Ophthalmoscopes
  • Pigment Epithelium of Eye / pathology*
  • Retinal Perforations / diagnosis*
  • Retinal Perforations / etiology

Substances

  • Indocyanine Green