Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents

Bioorg Med Chem. 1999 Sep;7(9):1907-11. doi: 10.1016/s0968-0896(99)00169-8.

Abstract

In our search for novel anti-HIV agents, seven 17-carboxylated steroid derivatives were synthesized and evaluated as potential anti-HIV agents. Compound 13 exhibited potent anti-HIV activity in acutely infected H9 lymphocytes with EC50 and therapeutic index values of 0.8 microM and 300, respectively.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / pharmacology
  • Cell Line
  • HIV-1 / drug effects
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Spectrum Analysis
  • Steroids / chemical synthesis*
  • Steroids / chemistry
  • Steroids / pharmacology

Substances

  • Anti-HIV Agents
  • Steroids