Abstract
Mucin-type O-glycans on leukocytes acquire functions once they contain core 2 branches, which can be synthesized by core 2 beta1,6-N-acetylglucosaminyltransferase (C2GnT). Recently, understanding the roles of mucin-type O-glycans has been significantly advanced by generating transgenic mice overexpressing C2GnT or knockout mice defective in C2GnT. This review article summarizes previous results implicating the roles of mucin-type O-glycans and the most recent studies to test such a hypothesis. These results, taken together, demonstrate that mucin-type O-glycans either facilitate or attenuate cell adhesion depending on the structures of non-reducing termini.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, CD / chemistry*
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Antigens, CD / genetics
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Biomarkers, Tumor / analysis
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Carbohydrate Sequence
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Cell Adhesion*
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Cell Line
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DNA, Complementary / chemistry
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Humans
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Leukosialin
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Lewis Blood Group Antigens
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Lewis X Antigen
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Molecular Sequence Data
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Molecular Weight
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Mucins / metabolism*
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N-Acetylglucosaminyltransferases / genetics
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N-Acetylglucosaminyltransferases / metabolism*
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Oligosaccharides / analysis
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Sialoglycoproteins / chemistry*
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Sialoglycoproteins / genetics
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T-Lymphocytes / chemistry
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T-Lymphocytes / enzymology
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T-Lymphocytes / immunology
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Thymus Gland / chemistry
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Thymus Gland / cytology
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Tumor Cells, Cultured
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Wiskott-Aldrich Syndrome / immunology
Substances
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Antigens, CD
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Biomarkers, Tumor
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DNA, Complementary
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Leukosialin
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Lewis Blood Group Antigens
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Lewis X Antigen
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Mucins
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Oligosaccharides
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SPN protein, human
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Sialoglycoproteins
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lewis(a)-lewis(x)
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N-Acetylglucosaminyltransferases
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beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
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beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-acetylglucosaminyl transferase