Abstract
Sodium borohydride reduction of 3-chloro-1-(2-thienyl)-1-propanone gave the corresponding racemic alcohol which was kinetically resolved with lipase B from Candida antarctica as catalyst to yield the chiral building blocks (S)-3-chloro-1-(2-thienyl)-1-propanol and the corresponding (R)-butanoate. The enantiopure chiral building blocks were converted into Duloxetine and its enantiomer.
Copyright 2000 Wiley-Liss, Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antidepressive Agents / chemical synthesis*
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Antidepressive Agents / isolation & purification
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Candida / enzymology
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Duloxetine Hydrochloride
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Kinetics
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Lipase / metabolism*
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Saccharomyces cerevisiae / enzymology
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Stereoisomerism
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Thiophenes / chemical synthesis*
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Thiophenes / isolation & purification
Substances
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Antidepressive Agents
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Thiophenes
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Duloxetine Hydrochloride
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Lipase