Abstract
Sodium 7beta-[(R)-2-(N(b)()-o-nitrobenzyloxycarbonyl)hydrazino-3-pheny lpropa namido]cephalosporanate (1) is described as a new type of beta-lactam antibiotic, which undergoes light-induced destruction of its beta-lactam moiety and hence becomes biologically inactive. This type of antibiotic holds the promise of self-destruction over a number of hours of exposure to light, so that it would not allow selection of resistance in the environment.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacteria / drug effects
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Carbamates / chemistry*
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Carbamates / pharmacology
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Carbamates / radiation effects
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Cephalosporins / chemistry*
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Cephalosporins / pharmacology
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Cephalosporins / radiation effects
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Light
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Photochemistry
Substances
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7-(2-(N(b)-2-nitrobenzyloxycarbonyl)hydrazino-3-phenylpropanamido)cephalosporanic acid
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Carbamates
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Cephalosporins