The origin of prokaryotic C2H2 zinc finger regulators

Trends Microbiol. 2000 Feb;8(2):77-81. doi: 10.1016/s0966-842x(99)01679-0.

Abstract

C2H2 zinc finger bearing proteins are a large superfamily of nucleic acid binding proteins, which constitute a major subset of eukaryotic transcription factors. Although originally thought to occur only in eukaryotes, a novel C2H2 zinc finger transcription factor, Ros, which regulates both prokaryotic and eukaryotic promoters has been found in bacteria. Phylogenically, Ros is distantly related to eukaryotic zinc finger regulators.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacteria / chemistry*
  • Bacteria / genetics
  • Bacteria / metabolism
  • Bacterial Proteins* / chemistry
  • Bacterial Proteins* / genetics
  • Bacterial Proteins* / metabolism
  • DNA-Binding Proteins* / chemistry
  • DNA-Binding Proteins* / genetics
  • DNA-Binding Proteins* / metabolism
  • Evolution, Molecular
  • Gene Expression Regulation
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Recombination, Genetic
  • Repressor Proteins* / chemistry
  • Repressor Proteins* / genetics
  • Repressor Proteins* / metabolism
  • Zinc Fingers* / genetics

Substances

  • Bacterial Proteins
  • DNA-Binding Proteins
  • Repressor Proteins