Abstract
IL-18 - a novel cytokine with potent IFN-gamma-inducing activities - plays an important role in the Th1-mediated immune response in collaboration with IL-12. IL-18 is a member of the IL-1 family. The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response.
MeSH terms
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Animals
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Immunity, Innate*
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Interferon-gamma / biosynthesis
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Interleukin-1 / pharmacology
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Interleukin-12 / pharmacology
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Interleukin-18 / pharmacology*
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Interleukin-18 Receptor alpha Subunit
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Killer Cells, Natural / immunology
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Mice
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Models, Immunological
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Receptors, Interleukin / genetics
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Receptors, Interleukin / metabolism*
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Receptors, Interleukin-18
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Signal Transduction
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Th1 Cells / immunology
Substances
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Il18r1 protein, mouse
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Interleukin-1
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Interleukin-18
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Interleukin-18 Receptor alpha Subunit
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Receptors, Interleukin
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Receptors, Interleukin-18
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Interleukin-12
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Interferon-gamma