Abstract
We have identified a novel human gene product, hMOF, which exhibits significant similarity to the Drosophila dosage compensation regulator, MOF. A recombinant C-terminal portion of hMOF has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic of other MYST family histone acetyltransferases. Based on hMOF's chromodomain, we discuss possible interactions with other proteins.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetyltransferases / chemistry
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Acetyltransferases / genetics*
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Amino Acid Sequence
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Dosage Compensation, Genetic
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Drosophila Proteins*
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Histone Acetyltransferases
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Humans
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Molecular Sequence Data
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Nuclear Proteins*
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Saccharomyces cerevisiae Proteins*
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Transfection
Substances
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Drosophila Proteins
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Nuclear Proteins
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Saccharomyces cerevisiae Proteins
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Acetyltransferases
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Histone Acetyltransferases
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KAT7 protein, human
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KAT8 protein, human
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mof protein, Drosophila
Associated data
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GENBANK/AF100615
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GENBANK/AF117065