Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity

Biochim Biophys Acta. 2000 May 17;1470(3):M79-91. doi: 10.1016/s0304-419x(00)00009-3.
No abstract available

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Apoptosis
  • Cell Cycle / drug effects
  • Cell Line
  • Cell Membrane Permeability / drug effects
  • Drug Resistance, Multiple
  • Drug Tolerance
  • Epothilones*
  • Epoxy Compounds / pharmacology*
  • Epoxy Compounds / therapeutic use
  • Epoxy Compounds / toxicity
  • Humans
  • Lactones / chemistry
  • Microtubules / drug effects*
  • Molecular Structure
  • Paclitaxel / pharmacology
  • Structure-Activity Relationship
  • Thiazoles / chemistry
  • Thiazoles / pharmacology*
  • Thiazoles / therapeutic use
  • Thiazoles / toxicity
  • Tubulin / chemistry
  • Tubulin / metabolism
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Epothilones
  • Epoxy Compounds
  • Lactones
  • Thiazoles
  • Tubulin
  • desoxyepothilone A
  • epothilone A
  • Paclitaxel
  • desoxyepothilone B
  • epothilone B