Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke

M D Hill; P A Barber; J Takahashi; A M Demchuk; T E Feasby; A M Buchan

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke

CMAJ. 2000 May 2;162(9):1281-4.

Authors

M D Hill¹, P A Barber, J Takahashi, A M Demchuk, T E Feasby, A M Buchan

Affiliation

¹ Department of Clinical Neurosciences, University of Calgary, Alta. michael.hill@crha-health.ab.ca

PMID: 10813008
PMCID: PMC1232409

Abstract

Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Anaphylaxis / chemically induced*
Anaphylaxis / diagnosis
Angioedema / chemically induced*
Angioedema / diagnosis
Cerebral Infarction / drug therapy*
Diagnosis, Differential
Drug Hypersensitivity / diagnosis*
Female
Humans
Infusions, Intravenous
Thrombolytic Therapy*
Tissue Plasminogen Activator / administration & dosage
Tissue Plasminogen Activator / adverse effects*

Substances

Tissue Plasminogen Activator