A marine diterpene with a novel tetracyclic framework from the West Indian gorgonian octocoral Pseudopterogorgia elisabethae

Org Lett. 2000 Feb 24;2(4):507-10. doi: 10.1021/ol991362i.

Abstract

[structure: see text] Colombiasin A (1) was isolated from an extract of the West Indian gorgonian octocoral Pseudopterogorgia elisabethae that showed strong inhibitorial activity against Mycobacterium tuberculosis H37Rv. Structure elucidation by interpretation of 2D-NMR spectroscopic data, IR, UV, and accurate mass measurements (HREI-MS) revealed that colombiasin A belongs to a previously undescribed class of C20 rearranged diterpenes possessing an intricate tetracyclic framework.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antitubercular Agents / chemistry*
  • Antitubercular Agents / pharmacology
  • Bridged-Ring Compounds / chemistry*
  • Bridged-Ring Compounds / pharmacology
  • Cnidaria / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects
  • Spectrum Analysis

Substances

  • Antitubercular Agents
  • Bridged-Ring Compounds
  • colombiasin A