Abstract
Apoptosis is a phenomenon of fundamental importance in embryonal development and the homeostatic regulation of mature tissue. We review the present knowledge on apoptosis and the evidence that apoptosis may play a role in the pathogenesis of human disease. As examples we discuss its role in cancer, ischemic diseases, heart failure and neurodegenerative diseases.
MeSH terms
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Apoptosis*
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Disease*
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Heart Failure / etiology
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Heart Failure / pathology
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Heart Failure / physiopathology
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Humans
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Ischemia / etiology
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Ischemia / pathology
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Ischemia / physiopathology
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Neoplasms / etiology
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Neoplasms / pathology
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Neoplasms / physiopathology
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Neurodegenerative Diseases / etiology
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Neurodegenerative Diseases / pathology
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Neurodegenerative Diseases / physiopathology