Abstract
Cyclic AMP (cAMP) is involved in the stress response in Saccharomyces cerevisiae. We show that cAMP is required for resistance to fluconazole in S. cerevisiae. In addition, activation of Ras2, a regulator of cAMP generation, results in some protection from fluconazole toxicity in a fashion independent of the efflux transporter Pdr5p.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antifungal Agents / pharmacology*
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Cyclic AMP / metabolism*
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Drug Resistance, Microbial*
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Fluconazole / pharmacology*
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Saccharomyces cerevisiae / drug effects*
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Saccharomyces cerevisiae / metabolism*
Substances
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Antifungal Agents
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Fluconazole
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Cyclic AMP