End-stage coxarthrosis and gonarthrosis. Aetiology, clinical patterns and radiological features of idiopathic osteoarthritis

Rheumatology (Oxford). 2000 Jun;39(6):612-9. doi: 10.1093/rheumatology/39.6.612.

Abstract

Objectives: To determine and compare the aetiological background, clinical patterns and radiological features of idiopathic osteoarthritis (OA) of the hip and the knee warranting arthroplasty.

Methods: A total of 402 Caucasians consecutively undergoing total hip replacement (THR) or total knee replacement (TKR) for idiopathic OA at a major centre was surveyed.

Results: Previous joint injury was more common in the TKR group (P < 0.0001). However, both groups manifested a mixed occupational background, body mass indices similar to the general population and a predominance of females (F:M = 1.3-1.4:1). The TKR group had a significantly younger age of symptom onset (56 yr) than the THR group (61 yr) but both groups had a tendency to bilateral arthroplasty (33%), nodal involvement (54-59%), a significant excess of right-sided replacements (1.8:1, THR; 2.2:1, TKR) and similar levels of pre-operative pain and disability. Up to 40% of hips manifested acetabular dysplasia and 10% possible previous slipped upper femoral epiphyses. Eighty-five per cent with end-stage coxarthrosis or gonarthrosis had an identical pattern of radiographic disease contralaterally.

Conclusions: Our data suggest the importance of a constitutional tendency to idiopathic, end-stage OA, a disorder traditionally associated with environmental factors leading to 'wear and tear'.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Analgesics / therapeutic use
  • Arthroplasty, Replacement, Hip
  • Arthroplasty, Replacement, Knee
  • Body Mass Index
  • Disease Progression
  • Female
  • Humans
  • Male
  • Middle Aged
  • Occupations
  • Osteoarthritis, Hip / diagnostic imaging
  • Osteoarthritis, Hip / etiology
  • Osteoarthritis, Hip / physiopathology*
  • Osteoarthritis, Knee / diagnostic imaging
  • Osteoarthritis, Knee / etiology
  • Osteoarthritis, Knee / physiopathology*
  • Pain / drug therapy
  • Pain / etiology
  • Radiography
  • Sex Factors
  • Total Quality Management

Substances

  • Analgesics