Abstract
Enhancement of the inhibitory activity of GABA may protect ischemic neurons. We evaluated the neuroprotective effect of tiagabine, a novel GABA agonist, in reversible focal cerebral ischemia rats subjected to 2h middle cerebral artery (MCA) occlusion. Tiagabine was given at 10, 20 and 40 mg/kg, i.p., 2 h after the onset of reperfusion. We found that post-ischemia treatment with tiagabine improved neurobehavioral outcome and reduced brain infarction volume in a dose-dependent manner. The data suggest that post-ischemic administration of tiagabine is neuroprotective in the focal cerebral ischemia model.
MeSH terms
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Animals
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Brain / pathology
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Cerebral Infarction / pathology
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Cerebral Infarction / prevention & control*
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Disease Models, Animal
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GABA Agonists / pharmacology
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Intracranial Embolism / pathology
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Intracranial Embolism / physiopathology
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Intracranial Embolism / prevention & control
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Ischemic Attack, Transient / pathology
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Ischemic Attack, Transient / physiopathology*
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Ischemic Attack, Transient / prevention & control*
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Male
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Middle Cerebral Artery
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Neuroprotective Agents / pharmacology*
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Nipecotic Acids / pharmacology*
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Rats
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Rats, Wistar
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Tiagabine
Substances
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GABA Agonists
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Neuroprotective Agents
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Nipecotic Acids
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Tiagabine