Abstract
The recent X-ray structures of the anti-apoptotic protein survivin reveal two different dimeric interfaces. More experiments are needed to determine the biologically relevant dimer interface and to probe survivin function on the basis of its structure.
MeSH terms
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Animals
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Apoptosis
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Binding Sites
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Chelating Agents / metabolism
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Crystallography, X-Ray
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Dimerization
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Humans
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Inhibitor of Apoptosis Proteins
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Mice
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Microtubule-Associated Proteins*
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Models, Molecular
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Neoplasm Proteins
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Protein Structure, Tertiary
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Proteins / chemistry*
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Proteins / metabolism*
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Structure-Activity Relationship
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Survivin
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Zinc / metabolism
Substances
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BIRC5 protein, human
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Chelating Agents
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Inhibitor of Apoptosis Proteins
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Microtubule-Associated Proteins
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Neoplasm Proteins
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Proteins
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Survivin
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Zinc