CD154 polymorphism in Spanish populations. Differences in the allelic distribution between Canary islanders and Peninsulars

M J Citores; P Pérez-Aciego; C Rodríguez-Gallego; B Contreras-Martín; I García-Laorden; A Durántez

doi:10.1046/j.1365-2370.2000.00220.x

CD154 polymorphism in Spanish populations. Differences in the allelic distribution between Canary islanders and Peninsulars

Eur J Immunogenet. 2000 Jun;27(3):141-4. doi: 10.1046/j.1365-2370.2000.00220.x.

Authors

M J Citores¹, P Pérez-Aciego, C Rodríguez-Gallego, B Contreras-Martín, I García-Laorden, A Durántez

Affiliation

¹ Fundación Lair, Laboratorio, Madrid, Spain.

PMID: 10940082
DOI: 10.1046/j.1365-2370.2000.00220.x

Abstract

The CD154 gene contains a dinucleotide repeat (CA)n in the 3' untranslated region. Allelic distribution in Spanish populations from two areas with different genetic background, the Canary Islands and Peninsula, are described. Seven alleles with different allelic distribution between the two groups, were found. This represents a highly polymorphic marker, useful for genetic studies on a critical molecule in immunity.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

3' Untranslated Regions / genetics
Alleles
CD40 Ligand
Dinucleotide Repeats / genetics
Electrophoresis
Female
Gene Frequency
Genetic Markers / genetics
Genetic Markers / immunology
Humans
Male
Membrane Glycoproteins / blood
Membrane Glycoproteins / genetics*
Membrane Glycoproteins / immunology
Polymorphism, Genetic / genetics*
Polymorphism, Genetic / immunology
Spain / epidemiology

Substances

3' Untranslated Regions
Genetic Markers
Membrane Glycoproteins
CD40 Ligand