Abstract
Fringe modifies the ligand-selectivity of Notch in ways that are crucial for a number of Notch's developmental functions. Recent results have confirmed the suspicion that Fringe is a glycosyltransferase that works in the Golgi complex by modifying Notch's glycosylation state.
MeSH terms
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Animals
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Drosophila Proteins
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Drosophila melanogaster / growth & development*
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Drosophila melanogaster / metabolism
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Gene Expression Regulation, Developmental
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Glycosyltransferases / metabolism*
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Insect Proteins / metabolism*
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Membrane Proteins / metabolism*
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N-Acetylglucosaminyltransferases*
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Receptors, Notch
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Signal Transduction / physiology
Substances
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Drosophila Proteins
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Insect Proteins
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Membrane Proteins
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N protein, Drosophila
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Receptors, Notch
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Glycosyltransferases
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N-Acetylglucosaminyltransferases
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fng protein, Drosophila