Notch signaling: Fringe really is a glycosyltransferase

Curr Biol. 2000 Aug 24;10(16):R608-12. doi: 10.1016/s0960-9822(00)00633-3.

Abstract

Fringe modifies the ligand-selectivity of Notch in ways that are crucial for a number of Notch's developmental functions. Recent results have confirmed the suspicion that Fringe is a glycosyltransferase that works in the Golgi complex by modifying Notch's glycosylation state.

MeSH terms

  • Animals
  • Drosophila Proteins
  • Drosophila melanogaster / growth & development*
  • Drosophila melanogaster / metabolism
  • Gene Expression Regulation, Developmental
  • Glycosyltransferases / metabolism*
  • Insect Proteins / metabolism*
  • Membrane Proteins / metabolism*
  • N-Acetylglucosaminyltransferases*
  • Receptors, Notch
  • Signal Transduction / physiology

Substances

  • Drosophila Proteins
  • Insect Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Notch
  • Glycosyltransferases
  • N-Acetylglucosaminyltransferases
  • fng protein, Drosophila