Antiphospholipid antibodies and the endothelium

Curr Rheumatol Rep. 2000 Jun;2(3):252-5. doi: 10.1007/s11926-000-0087-6.

Abstract

This article reviews current understanding of the relationship between antiphospholipid antibodies and the endothelium. In vitro antiphospholipid antibodies produce endothelial cell activation. Clinical data in this area are scanty and worthy of future research, which could lead to new therapies in the management of antiphospholipid syndrome.

Publication types

  • Review

MeSH terms

  • Antibodies, Antiphospholipid / immunology
  • Antibodies, Antiphospholipid / metabolism*
  • Antiphospholipid Syndrome / complications
  • Antiphospholipid Syndrome / immunology
  • Antiphospholipid Syndrome / metabolism*
  • Arteriosclerosis / etiology*
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism*
  • Humans
  • Hypolipidemic Agents / pharmacology
  • Lipoproteins / metabolism
  • Thrombosis / etiology

Substances

  • Antibodies, Antiphospholipid
  • Hypolipidemic Agents
  • Lipoproteins
  • lipoprotein-associated coagulation inhibitor