Use of topical cyclosporin for conjunctival manifestations of actinic prurigo

Am J Ophthalmol. 2000 Dec;130(6):830-1. doi: 10.1016/s0002-9394(00)00619-x.

Abstract

Purpose: To report the successful treatment of conjunctival manifestations of actinic prurigo with topical cyclosporin.

Methods: A 12-year-old female with extensive limbal lesions and chronic conjunctivitis secondary to actinic prurigo was treated with topical cyclosporin, and a rapid clinical response was observed.

Results: The patient had the limbal lesions surgically excised. The lesions completely recurred over the first 2 postoperative months. Treatment with topical steroids and vitamin A ointment was unsuccessful. The patient was then treated with cyclosporine 2% drops and a dramatic improvement occurred. Over a 3-month period, the lesions completely resolved.

Conclusion: Cyclosporine eyedrops may be an effective treatment for the conjunctival manifestations of actinic prurigo.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Child
  • Conjunctivitis / drug therapy*
  • Conjunctivitis / etiology
  • Conjunctivitis / pathology
  • Cyclosporine / administration & dosage
  • Cyclosporine / therapeutic use*
  • Female
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / therapeutic use*
  • Ophthalmic Solutions
  • Photosensitivity Disorders / complications
  • Photosensitivity Disorders / drug therapy*
  • Photosensitivity Disorders / pathology
  • Prurigo / complications
  • Prurigo / drug therapy*
  • Prurigo / pathology

Substances

  • Immunosuppressive Agents
  • Ophthalmic Solutions
  • Cyclosporine