Abstract
To test the hypothesis that increased androgenic activity is involved in breast cancer, the urinary testosterone was assayed in 19 clinically cured breast cancer patients and in 22 patients developing metastases from breast cancer during the same period of observation (5 to 15 years after mastectomy). The levels in the clinically cured patients were near normal whereas those in patients with metastases were significantly above normal.
MeSH terms
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Age Factors
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Aged
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Androgens / metabolism*
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Androgens / urine
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Breast Neoplasms / complications
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Breast Neoplasms / etiology
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Breast Neoplasms / physiopathology
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Breast Neoplasms / prevention & control*
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Breast Neoplasms / surgery
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Breast Neoplasms / urine
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Castration
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Endometrial Hyperplasia / etiology
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Endometrial Hyperplasia / pathology
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Female
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Humans
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Mastectomy
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Menopause
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Middle Aged
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Neoplasm Metastasis
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Neoplasm Recurrence, Local / prevention & control*
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Ovarian Neoplasms / etiology
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Ovarian Neoplasms / surgery
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Ovary / pathology
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Ovary / physiopathology
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Testosterone / urine
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Time Factors