Abstract
The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-gamma in IL-12-deficient mice. Although IL-12-deficient mice were exposed to higher staphylococcal load, they demonstrated no increased severity of arthritis as compared with control animals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arthritis, Infectious / blood
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Arthritis, Infectious / immunology*
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Arthritis, Infectious / microbiology*
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Colony Count, Microbial
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Interferon-gamma / biosynthesis
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Interferon-gamma / blood
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Interleukin-12 / biosynthesis
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Interleukin-12 / deficiency
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Interleukin-12 / genetics
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Interleukin-12 / physiology*
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Joints / microbiology
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Kidney / microbiology
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Liver / microbiology
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Sepsis / immunology*
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Sepsis / microbiology
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Staphylococcal Infections / immunology*
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Staphylococcus aureus / immunology
Substances
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Interleukin-12
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Interferon-gamma