Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis

Arthritis Res. 2001;3(1):41-7. doi: 10.1186/ar138. Epub 2000 Nov 3.

Abstract

The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-gamma in IL-12-deficient mice. Although IL-12-deficient mice were exposed to higher staphylococcal load, they demonstrated no increased severity of arthritis as compared with control animals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arthritis, Infectious / blood
  • Arthritis, Infectious / immunology*
  • Arthritis, Infectious / microbiology*
  • Colony Count, Microbial
  • Interferon-gamma / biosynthesis
  • Interferon-gamma / blood
  • Interleukin-12 / biosynthesis
  • Interleukin-12 / deficiency
  • Interleukin-12 / genetics
  • Interleukin-12 / physiology*
  • Joints / microbiology
  • Kidney / microbiology
  • Liver / microbiology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Sepsis / immunology*
  • Sepsis / microbiology
  • Staphylococcal Infections / immunology*
  • Staphylococcus aureus / immunology

Substances

  • Interleukin-12
  • Interferon-gamma