p53 and p21 are major cellular determinants for DNA topoisomerase I-mediated radiation sensitization in mammalian cells

Ann N Y Acad Sci. 2000:922:298-300. doi: 10.1111/j.1749-6632.2000.tb07047.x.

Authors

A Y Chen¹, P B Scruggs, L Geng, M L Rothenberg, D E Hallahan

Affiliation

¹ Department of Radiation Oncology, Vanderbilt University Medical Center, 1301 22nd Ave. S., Vanderbilt Clinic, Nashville, TN 37232-5671, USA. Allan.chen@mcmail.vanderbilt.edu

PMID: 11193905
DOI: 10.1111/j.1749-6632.2000.tb07047.x

No abstract available

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / pharmacology
CHO Cells / drug effects
CHO Cells / radiation effects
Camptothecin / pharmacology
Cricetinae
Cyclin-Dependent Kinase Inhibitor p21
Cyclins / physiology*
DNA Topoisomerases, Type I / physiology*
Enzyme Inhibitors / pharmacology
Humans
Radiation Tolerance / drug effects
Radiation Tolerance / physiology*
Radiation-Sensitizing Agents / pharmacology
Topoisomerase I Inhibitors
Tumor Cells, Cultured / drug effects
Tumor Cells, Cultured / radiation effects
Tumor Suppressor Protein p53 / physiology*

Substances

Antineoplastic Agents, Phytogenic
CDKN1A protein, human
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Enzyme Inhibitors
Radiation-Sensitizing Agents
Topoisomerase I Inhibitors
Tumor Suppressor Protein p53
DNA Topoisomerases, Type I
Camptothecin