Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship

Y G Suh; Y H Kim; M H Park; Y H Choi; H K Lee; J Y Moon; K H Min; D Y Shin; J K Jung; O H Park; R O Jeon; H S Park; S A Kang

doi:10.1016/s0960-894x(01)00004-x

Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship

Bioorg Med Chem Lett. 2001 Feb 26;11(4):559-62. doi: 10.1016/s0960-894x(01)00004-x.

Authors

Y G Suh¹, Y H Kim, M H Park, Y H Choi, H K Lee, J Y Moon, K H Min, D Y Shin, J K Jung, O H Park, R O Jeon, H S Park, S A Kang

Affiliation

¹ College of Pharmacy, Seoul National University, South Korea. ygsuh@plaza.snu.ac.kr

PMID: 11229771
DOI: 10.1016/s0960-894x(01)00004-x

Abstract

The structure-activity relationship and molecular modelings of a novel pimarane COX-2 inhibitor are reported. Particularly, a series of linker extended analogues designed on the basis of these studies exhibited significantly enhanced COX-2 inhibitory activities and selectivities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / chemical synthesis*
Cyclooxygenase Inhibitors / pharmacology
Diterpenes / chemical synthesis*
Diterpenes / pharmacology
Isoenzymes / antagonists & inhibitors*
Prostaglandin-Endoperoxide Synthases
Structure-Activity Relationship

Substances

Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Diterpenes
Isoenzymes
acanthoic acid
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases