Severe hepatic injury associated with lipid formulations of amphotericin B

Clin Infect Dis. 2001 Mar 1;32(5):E87-9. doi: 10.1086/319201. Epub 2001 Feb 23.

Abstract

A 14-year-old girl with leukemia had Doppler ultrasound evidence of hepatic necrosis, thought to be caused by a lipid formulation of amphotericin B, which has not been previously reported. It seems prudent to exert caution when retreating patients with previous hepatocellular damage with lipid formulations of amphotericin B.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Amphotericin B / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Chemical and Drug Induced Liver Injury*
  • Cytarabine / therapeutic use
  • Etoposide / therapeutic use
  • Female
  • Humans
  • Idarubicin / therapeutic use
  • Leukemia, Myeloid / complications
  • Leukemia, Myeloid / drug therapy
  • Liposomes
  • Liver / pathology*
  • Liver Diseases / pathology

Substances

  • Liposomes
  • liposomal amphotericin B
  • Cytarabine
  • Etoposide
  • Amphotericin B
  • Idarubicin

Supplementary concepts

  • ICE protocol 4