Abstract
Various components of garlic and aged garlic extract, including allicin, S-allylcysteine (SAC) and volatile metabolites of allicin were determined in breath, plasma and simulated gastric fluids by HPLC, gas chromatography (GC) or HPLC- and GC-mass spectrometry (MS). Data indicate that allicin decomposes in stomach acid to release allyl sulfides, disulfides and other volatiles that are postulated to be metabolized by glutathione and/or S-adenosylmethionine to form allyl methyl sulfide. SAC can be absorbed by the body and can be determined in plasma by HPLC or HPLC-MS using atmospheric pressure chemical ionization (APCI)-MS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Allyl Compounds / metabolism
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Breath Tests
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Chromatography, Gas / methods
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Chromatography, High Pressure Liquid / methods
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Cysteine / analogs & derivatives*
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Cysteine / blood
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Cysteine / metabolism*
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Disulfides
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Garlic / chemistry
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Garlic / metabolism*
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Gas Chromatography-Mass Spectrometry / methods
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Gastrointestinal Contents / chemistry*
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Glutathione / metabolism
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Humans
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Plant Extracts / chemistry
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Plant Extracts / metabolism
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Plants, Medicinal*
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S-Adenosylmethionine / metabolism
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Sulfides / metabolism
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Sulfinic Acids / analysis
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Sulfinic Acids / metabolism*
Substances
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Allyl Compounds
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Disulfides
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Plant Extracts
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Sulfides
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Sulfinic Acids
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allicin
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allyl sulfide
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S-Adenosylmethionine
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S-allylcysteine
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Glutathione
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Cysteine